Published 2015 | Version v1
Dataset Open

Rhesus Macaque Fibroblast

  • 1. ROR icon California Institute of Technology

Description

Express native levels of untagged TRIM5α. Can see RAVs in fibroblasts for the first time. Most of these cells actually cells displayed mainly auto fluorescent puncta and probably did not correlate any virus because light image only taken in the red channel.

Technical info

Tilt Series Date: 2015-04-20

Data Taken By: Stephen Carter

Species / Specimen: Rhesus Macaque Fibroblasts infected with Vpr-Ruby HIV-1

Strain:

Tilt Series Settings: Single Axis, tilt range: (-60.0°, 60.0°), step: 1°, constant angular increment, dosage: 150.0 eV/Ų, defocus: -10.0 μm, magnification: 18000x.

Acquisition Software: UCSFTomo

Upload Method: reupload_downloaded

Processing Software Used: IMOD

Collaborators and Roles: Fibroblasts VSV-G pseudotyped virus Vpr-Ruby provided by Tom Hope

Purification / Growth Conditions / Treatment: Cells infected with ZLK 106-06-06-14 HIV-1 GFP Vpr Ruby. 500 µl of media and 500 µl of virus. Virus spinoculated at 16°C at 18 g for 1 hr. Cells were washed with warm media and incubated at 37°C. Cells frozen at early time points approximately 20 mins after temperature shift.

Attached Files

tomography2.mrc, Tilt Series (Pixel Size 0.6 nm), 3.4 GB

tomography2_full.rec, Reconstruction (Pixel Size 0.0 nm), 666.7 MB

Files

keyimg_scd2015-04-20-2.jpg

Files (4.1 GB)

Name Size
md5:d240712cab574da94376206de9296ce9
393.4 kB Preview Download
md5:009e8da9268ae3308985e9eee7711624
15.8 MB Preview Download
3.4 GB (external) Download
666.7 MB (external) Download

Additional details

Identifiers

DOI
10.22002/qr58h-ge781
TILT_SERIES_ID
scd2015-04-20-2

Funding

NIH
HHMI
Beckman Institute
Gordon and Betty Moore Foundation
Agouron Institute
John Templeton Foundation

Dates

Collected
2015-04-20
Created
2015-04-20
Updated
2016-07-13