Published 2017 | Version v1
Dataset Open

LCV_Legionella pneumophila

  • 1. ROR icon California Institute of Technology

Description

THP1 cells were infected with Legionella wild type cells and thereafter phagosomes (LCV) were purified by sucrose density gradient method. Phagoseomes were fixed before shipment.

Technical info

Tilt Series Date: 2017-06-01

Data Taken By: Debnath Ghosal

Species / Specimen: Legionella pneumophila

Strain: Philadelphia-1_Lp02

Tilt Series Settings: Single Axis, tilt range: (-54.0°, 54.0°), step: 2°, constant angular increment, dosage: 110.0 eV/Ų, defocus: -7.0 μm, magnification: 27500x.

Microscope: Caltech Polara

Acquisition Software: UCSFTomo

Upload Method: pipeline

Processing Software Used: Raptor

Collaborators and Roles: Joelle Gabay and Howard Shuman prepared samples, Debnath Ghosal collected data.

Purification / Growth Conditions / Treatment: Phagosome isolation method as described by Joelle Gabay (Endnote).

Sample Preparation: 6 grids were frozen, cell density was increased to 2x by centrifugation. Vitrobot (MK iv) settings: 100% humidity, 4µl sample, Blot force 6, blot time 4.5 sec. Wait time 0 sec. Drain time 1 sec. Ethane/propane mix. Grid: Quantifoil Cu 2/2 200. Add gold to cells prior to freezing: 1ul of gold to 4 ul of cells, freeze.

Attached Files

LCV_201706010013.mrc, Tilt Series (Pixel Size 0.39 nm), 797.5 MB

LCV_201706010013.rec, Reconstruction (Pixel Size 1.56 nm), 890.9 MB

Files

keyimg_dga2017-06-01-13.jpg

Files (1.7 GB)

Name Size
md5:0b005ab5da2aedd17f4f21b2f9cd7efc
1.1 MB Preview Download
md5:62032352d039e180026fbb7fe5a96f95
4.1 MB Preview Download
797.5 MB (external) Download
890.9 MB (external) Download

Additional details

Identifiers

DOI
10.22002/znshm-g4p28
TILT_SERIES_ID
dga2017-06-01-13

Funding

NIH
HHMI
Beckman Institute
Gordon and Betty Moore Foundation
Agouron Institute
John Templeton Foundation

Dates

Collected
2017-06-01
Created
2017-06-05
Updated
2017-07-05