In multicellular organisms, cell types must be produced and maintained in appropriate proportions. One way this is achieved is through committed progenitor cells that produce specific sets of descendant cell types. However, cell fate commitment is probabilistic in most contexts, making it difficult to infer progenitor states and understand how t...

In multicellular organisms, cell types must be produced and maintained in appropriate proportions. One way this is achieved is through committed progenitor cells or extrinsic interactions that produce specific patterns of descendant cell types on lineage trees. However, cell fate commitment is probabilistic in most contexts, making it difficult ...

Data and code repository for paper "Periodic spatial patterning with a single morphogen"

Data and code repository for paper "Periodic spatial patterning with a single morphogen"

This deposit contains the raw and processed data and documents for the article, 'Combinatorial expression motifs in signaling pathways.' Code and analysis (organized by figure) are available at the GitHub repository https://github.com/nkanrar/motifs and Caltech DATA https://data.caltech.edu/records/bgm15-18g17. Please see the related publication...

This deposit contains the code and analysis for the manuscript, 'Combinatorial expression motifs in signaling pathways.' Data are available at the CaltechDATA repository https://. Please see the related publication for more details, and contact the corresponding authors for any questions.

This dataset contains the raw data, data processing codes, and figures for the manuscript 'miRNA circuit modules for tunable dosage compensated gene expression'. Bulk RNAseq raw data is available upon request from the authors.

Data and code repository for paper "Synthetic multistability in mammalian cells"

Many biological signaling pathways employ proteins that competitively dimerize in diverse combinations. These dimerization networks can perform biochemical computations, in which the concentrations of monomers (inputs) determine the concentrations of dimers (outputs). Despite their prevalence, little is known about the range of input-output comp...

Here we provide raw data, code, and other supplementary material related to the manuscript, "Reconstitution of morphogen shuttling circuits," by Ronghui Zhu et al. This includes computer codes for implementing the shuttling model, maps of constructs used in this manuscript, raw imaging and flow cytometry data, and raw time-lapse images.